The Van Andel Research Institution in Grand Rapids, MI needs additional
samples from Beagles diagnosed with hemangiosarcoma !
The CHCC (Canine Hereditary Cancer Consortium) is requesting samples from
beagles who have had hemangiosarcoma (usually splenic tumors). We simply need
three mls of whole blood in an EDTA (purple top) tube.
We are comparing the DNA of dogs who develop hemangiosarcoma to the DNA of dogs
who do not have the disease. These DNA studies are designed to help us develop
better treatments, earlier diagnostics and perhaps DNA tests to serve as another
tool in the breeders' toolbox.
The CHCC will pay for the shipping of samples from affected dogs.
Please contact Roe Froman, DVM, for more specific information regarding sample
submission. Thank you for your help!
A diagnosis of cancer is a frightening thing, whether you’re receiving the information about yourself, or a loved one. When that loved one is your dog, it can be all the more confusing, since they can’t tell you where it hurts. A recent poll of parent clubs determined that cancer in general is the greatest health concern for owners and breeders. That same poll listed Hemangiosarcoma as the second greatest health concern.>
Hemangiosarcoma is a type of cancer
in the cells that line blood vessels. Tumors usually develop in the
heart, or liver, although they can also been found in the skin, bone,
brain, and other locations. Hemangiosarcoma is almost always malignant, and
tends todevelop slowly, but spread
rapidly, so that clinical
signs are often not noticeable until the tumors have metastasized and/or
ruptured, causing acute shock and
signs of hemangiosarcoma include loss of
arrhythmias, weight loss, weakness, lethargy, collapse, pale mucous
and/or sudden death. The most severe signs are caused from acute blood
These can vary from an enlarged abdomen due to hemorrhage to bleeding
lungs or the pleural space (outside the lungs) that compromises
bleeding into the heart sac that prevents the heart from beating
Metastasis is most commonly to the liver, stomach
lungs, or brain.
first line of treatment, whenever possible, is removal of the tumor
affected organ, such as with a splenectomy.
standard of care includes chemotherapy as a follow-up to surgery.
Unfortunately, visceral hemangiosarcoma
that occurs in organs other than the skin) is most often fatal even
treatment, usually within weeks to months. However, approximately 10% to 15% of dogs
excellent response to treatment with durable remission and extended
We do not know why some tumors respond so well while most fail.>
Hemangiosarcomas of the skin may be
treated if the tumor hasn’t metastasized to other internal organs. In
to turn the tide in the outcome of this horrible diagnosis, the AKC
Health Foundation has approved nearly $900,000 in grant funds to
research focused on three aspects of hemangiosarcoma.
These different approaches to solving the hemangiosarcoma
puzzle often overlap – which
a better chance of finding answers and letting our dogs live longer.>
began by researching the biological behavior of hemangiosarcoma.
This means that they looked at the tumors to see how they behaved under
different circumstances. Knowing how a tumor behaves can provide
which treatments are most effective, and can also provide valuable
for the development of novel therapies that can target that specific
research of hemangiosarcoma looks for more
“genetic cause” of cancer in a particular breed. Investigators also
mutations in tumor suppressor genes (genes that prevent the division of
or promote cell death) and/or oncogenes
promote cell division and survival). These changes in genetic makeup
provide information on genetic risk factors (risk factors that have
do with environmental triggers), early detection and diagnosis and effectiveness of
Hopefully, this research will eventually lead to determining the
outcome of treatments, and potentially even treatments themselves.
into new, more effective therapies for hemangiosarcoma
includes more than just treatment of the actual tumors. Scientists are
looking for ways to prevent tumors from developing in dogs with a
(a vaccine of sorts). Novel treatments in development also include gene
therapies and immunotherapy. Gene therapy can be used when a mutation
to exist. In most cases of genetic disease, the correct gene (without
mutation) is inserted into a cell or tissue to replace the mutant gene.
Corrective gene therapy is unlikely to succeed in cancer because every
the tumor would have to be provided with the gene in a stable manner.
scientists are instead working to develop approaches that deliver genes
restricted number of cells as a way to activate the immune system or to
the local tumor enviroment as a way to
disease. Immunotherapy is a strategy based on the concept of altering the patient’s immune
that it fights cancer cells as it would a bacteria or virus.
therapies use special delivery systems to specifically target the tumor
only, thereby preventing damage to surrounding healthy cells. Studies
already shown that there are certain breeds that are at higher risk for
However, it can affect any dog, purebred or mixed breed alike.
Hemangiosarcoma is currently a fatal disease. By funding research, the AKC Canine Health Foundation hopes to provide owners and breeders with a means for earlier, more accurate diagnosis, more effective treatments, and ultimately prevention strategies. You can help by participating in clinical trials (visit the Veterinary Cancer Society website at www.vetcancersociety.org" for a list of active trials) and/or providing financial support to the Canine Health Foundations efforts (visit www.akcchf.org to make a secure online donation).
you would like additional information about the research the CHF is
funding on hemangiosarcoma,
visit our website at www.akcchf.org" and click on